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Scale bars?=?10 um. To measure possible embryonic lethality associated with Koh pets, timed matings had been carried out making use of Het mothers and fathers. Normal Mendelian proportions ended up observed at E12.5 with regard to Knock out (Figure?2A), suggesting that the H3f3b knockout phenotype mainly creates lethality from the second half regarding embryogenesis. Even so, the majority of KO E1
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