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Gnosis and increased mortality [49,50]. The mechanism underlying this differential glucose uptake between well-differentiated PTC and ATC is not well understood. The novel finding that TXNIP expression is low in ATC is consistent with the observed FDG uptake on PET/CT in patients with ATC, supporting a critical role for TXNIP as a metabolic regulator in thyroid cancer progression. In addition to i
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Inter-quartile after normalization on the reference gene set. cP for Spearman rank correlation test. dP for Mann-Whitney U test. eP for Kruskal-Wallis test, including a Wilcoxon-type test for trend when appropriate. fWith quantitative polymerase chain reaction cut point for positive versus negative ESR1 and PGR, 0.2 and 0.1, respectively, and for ESR2 at the median level of 0.005 (mRNA levels rela
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Inter-quartile after normalization on the reference gene set. cP for Spearman rank correlation test. dP for Mann-Whitney U test. eP for Kruskal-Wallis test, including a Wilcoxon-type test for trend when appropriate. fWith quantitative polymerase chain reaction cut point for positive versus negative ESR1 and PGR, 0.2 and 0.1, respectively, and for ESR2 at the median level of 0.005 (mRNA levels rela
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Friends: Here…There…Everywhere!!! was written to enhance social and literacy development in young children, ages two to five. Growth occurs...
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Promoting a pro-apoptotic environment [13,15-20]. Independent of its interaction with thioredoxin, TXNIP also has the ability to inhibit cell cycle progression by indirectly stabilizing the cell cycle inhibitor p27Kip1 [9]. In addition, TXNIPMorrison et al. Molecular Cancer 2014, 13:62 http://www.molecular-cancer.com/content/13/1/Page 8 ofAvectorB*** *TXNIPCD******Figure 5 TXNIP overexpression in
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Inter-quartile after normalization on the reference gene set. cP for Spearman rank correlation test. dP for Mann-Whitney U test. eP for Kruskal-Wallis test, including a Wilcoxon-type test for trend when appropriate. fWith quantitative polymerase chain reaction cut point for positive versus negative ESR1 and PGR, 0.2 and 0.1, respectively, and for ESR2 at the median level of 0.005 (mRNA levels rela
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The mechanisms by which TXNIP is expressed and functions in thyroid cancer will improve our understanding of the progression to advanced thyroid cancer and help to develop more effective targeted therapies.MethodsCell lines and maintenanceConclusions In conclusion, we report that TXNIP is a novel tumor suppressor in thyroid cancer. TXNIP is downregulated during the progression from well-differenti
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