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That half of the risk is likely due to environmental factors that may either be shared or not shared [16] . Many of the mutations that have been implicated in ASD by genetic studies reside in genes that encode proteins associated with synaptic function, transcriptional regulation and chromatin-remodeling [12] . The functional diversity of genes implicated in ASD suggests the possibility that the e
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He expression of distinct and likely overlapping gene sets. It seems plausible that the transcriptome of affected individuals reflects contributions from both the genetic background (genotype) and from environmentally mediated changes to the developmental transcription program. In other words, even though ASD is considered a complex genetic disorder, the complexity lies not only in the genetics, b
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He expression of distinct and likely overlapping gene sets. It seems plausible that the transcriptome of affected individuals reflects contributions from both the genetic background (genotype) and from environmentally mediated changes to the developmental transcription program. In other words, even though ASD is considered a complex genetic disorder, the complexity lies not only in the genetics, b
1
He expression of distinct and likely overlapping gene sets. It seems plausible that the transcriptome of affected individuals reflects contributions from both the genetic background (genotype) and from environmentally mediated changes to the developmental transcription program. In other words, even though ASD is considered a complex genetic disorder, the complexity lies not only in the genetics, b
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T may evidence sensitivity to energetic resources, and trade-offs with other demands. The constant production of cells andproteins required for immune vigilance is an important part of the energetic budget of organisms. The results of this paper support an understanding of investment in normal immunocompetence as a non-trivial energetic expense, one which may be drawn upon if needed to support oth
1
T may evidence sensitivity to energetic resources, and trade-offs with other demands. The constant production of cells andproteins required for immune vigilance is an important part of the energetic budget of organisms. The results of this paper support an understanding of investment in normal immunocompetence as a non-trivial energetic expense, one which may be drawn upon if needed to support oth
1
The observation that 70 of children diagnosed with idiopathic ASD exhibit comorbid medical, developmental or psychiatric conditions [3,6] , including intellectual disability [7] . According to one review, over 100 genes have been linked to syndromic forms of autism [8] . In addition, therepart of10.2217/epi.15.92 ?Dennis R GraysonEpigenomics (2016) 8(1), 85?ISSN 1750-PerspectiveGrayson Guidotti
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The observation that 70 of children diagnosed with idiopathic ASD exhibit comorbid medical, developmental or psychiatric conditions [3,6] , including intellectual disability [7] . According to one review, over 100 genes have been linked to syndromic forms of autism [8] . In addition, therepart of10.2217/epi.15.92 ?Dennis R GraysonEpigenomics (2016) 8(1), 85?ISSN 1750-PerspectiveGrayson Guidotti