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Calization of CRH and p-NR1 in the PVN. A-C: Sections from EA-treated naive rats were double-labeled with anti-CRH (red) and antip-NR1 (green). A: CRH-immunoreactive neurons in the PVN. B: p-NRI-immunoreactive neurons in the PVN. C: Merged graphs of A and B. Small arrows indicate examples of double-labeled CRH/p-NR1 neuron (yellow); Arrowheads point to single-labeled CRH and p-NR1. The insets in A
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Together, these studies suggest that EA action involves a variety of PVN chemicals. It is also noticed that ACTH(11?4) did not block EA antihyperalgesia, suggesting that endogenous ACTH plays little role in EA anti-hyperalgesia. Previous studies using HYPOX showed that the pituitary gland was involved in acupuncture analgesia [7,8]. The discrepancy between previous studies and ours may be due to t
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Together, these studies suggest that EA action involves a variety of PVN chemicals. It is also noticed that ACTH(11?4) did not block EA antihyperalgesia, suggesting that endogenous ACTH plays little role in EA anti-hyperalgesia. Previous studies using HYPOX showed that the pituitary gland was involved in acupuncture analgesia [7,8]. The discrepancy between previous studies and ours may be due to t
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Calization of CRH and p-NR1 in the PVN. A-C: Sections from EA-treated naive rats were double-labeled with anti-CRH (red) and antip-NR1 (green). A: CRH-immunoreactive neurons in the PVN. B: p-NRI-immunoreactive neurons in the PVN. C: Merged graphs of A and B. Small arrows indicate examples of double-labeled CRH/p-NR1 neuron (yellow); Arrowheads point to single-labeled CRH and p-NR1. The insets in A
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E rats in response to the same EA treatment suggests that EA affects healthy and pathological conditions differently. This is supported by a previous study reporting that naloxone completely blocked EA analgesia in healthy rats but partly blocked EA antihyperalgesia in carrageenan-induced inflammatory rats [23]. Collectively, these studies suggest that EA works differently in healthy and pathologi
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Than do healthy rats [23], it is possible that although EA does not produce stress in naive rats it may induce stress in inflamed rats. However, our previous study demonstrated that the same stimulation intensity at acupoint GB30 as that used in this study did not significantly change heart rate or blood pressure, both of which are indicators of stress response, in CFA-inflamed animals [2]. This s
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Oots TP: Detection of human bocavirus in respiratory, fecal, and blood samples by real-time PCR. J Med Virol 2009, 493(November 2008):488?93. Dang X, Bialasiewicz S, Nissen MD, Sloots TP, Koralnik IJ, Tan CS: Infrequent detection of KI. WU and MC polyomaviruses in immunosuppressed individuals with or without progressive multifocal leukoencephalopathy. PloS One 2011, 6:e16736. Pryce TM, Palladino S
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Oots TP: Detection of human bocavirus in respiratory, fecal, and blood samples by real-time PCR. J Med Virol 2009, 493(November 2008):488?93. Dang X, Bialasiewicz S, Nissen MD, Sloots TP, Koralnik IJ, Tan CS: Infrequent detection of KI. WU and MC polyomaviruses in immunosuppressed individuals with or without progressive multifocal leukoencephalopathy. PloS One 2011, 6:e16736. Pryce TM, Palladino S