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On IRF5 in human SLE cohorts have shown that the risk variant predisposes to greater serum IFN-, supporting the idea that the risk haplotype is a gain-offunction variant [22]. The same risk variant has been associated with autoantibody formation in SLE patients and in healthy individuals, and most of the risk of SLE related to IRF5 genotype is found within the autoantibody positive, high IFN group
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