Of STING reduces the overproduction of IFN and chronic inflammation [90]. Supporting this idea, gain-of-function mutations in TMEM173, gene encoding STING, were recently reported in subjects with a monogenic condition characterized by high IFN levels and vascular and pulmonary inflammation [91, 92]. Loss-of-function polymorphisms for STING are also known, however they have not yet been linked to a
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