Nducing IFN- and IFNinduced genes downstream of Toll-like receptor (TLR) activation. Additionally they play prominent role in cytokine secretion, cellular apoptosis, immune cell development, tumor suppression, and cell activation and differentiation [38, 39]. Interestingly, genetic variations in three of the nine IRFs (IRF5, IRF7, and IRF8) have been linked to SLE susceptibility, supporting a key
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